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Dołączył: 05 Maj 2011
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 Wysłany: Sob 4:18, 14 Maj 2011 Temat postu: Abercrombie Deutschland,Detection of serum choli |
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Detection of serum cholinesterase activity of plasma exchange analysis
Abstract of Serum cholinesterase (ChE) in plasma exchange before and after the change and clinical significance. Methods of automatic biochemical analyzer, Hitachi, our hospital patients with plasma exchange therapy in 11 patients (including 9 cases of severe hepatitis B, 2 cases of organophosphate poisoning) in the blood testing before and after replacement of ChE activity. Results The preoperative mean ChE activity (3 118.4 ± 538.6) U / L, replacement of ChE activity after a mean (4 996.2 ± 625.3) U / L, after statistical processing, the difference was significant (t = 7.546,[link widoczny dla zalogowanych], P
Key words Plasma exchange; cholinesterase; organic phosphorus poisoning; severe hepatitis B
】 【Abstract Objective To investigate the change and its clinical significance of the serum cholinesterase before and after plasma exchange (PE). Methods 11 cases (9 cases with severe hepatitis B and 2 with organic phosphate poisoning) were phlebotomized before and after PE to check the ChE by Hitachi auto biochemical analyzer. Results The average ChE is (3 118.4 ± 538.6) U / L before PE and (4 996.2 ± 625.3) U / L after it.The difference had statistical significance (t = 7.546,[link widoczny dla zalogowanych], P 】 【Key words Plasma exchange; Cholinesterase; Organic phosphate poisoning; Severe hepatitis B
Plasma exchange is one of blood purification therapy. The method is to use the blood cell separator to separate whole blood into plasma and cellular components (red blood cells, white blood cells and platelets), and according to clinical needs, the whole plasma or plasma in patients with sub-components or removal of certain cell components,[link widoczny dla zalogowanych], and with healthy human plasma or plasma substitutes to substitute, to achieve the purpose of treating disease. Severe hepatitis and in patients with organophosphate poisoning, timely application of plasma exchange treatment can quickly remove toxins, increase serum cholinesterase (ChE) activity, to restore and improve the success rate of disease to gain time. 11 patients in our hospital for plasma exchange, and the replacement before and after the detection of ChE activity, the results are analyzed as follows.
1 Materials and Methods
1.1 General Information selection in November 2006 ~ June 2007 in our hospital 11 patients, including 9 cases of chronic severe hepatitis B, 2 cases of organophosphate poisoning. By AK200 ULTRAL blood cell separator,[link widoczny dla zalogowanych], using saline and fresh frozen plasma as replacement fluid, exchange volume 3 000 ml / second, 11 patients were in the plasma exchange therapy before and 2 h after replacement of blood ChE activity detection.
1.2 Detection of ChE activity was determined by enzyme kinetic method, reagents purchased from Medical Science Co., Ltd. Shanghai Fuxing Long March. Instrumentation for the Hitachi 7180 automatic biochemical analyzer (instrument calibration on a regular basis, internal quality control testing to do before,[link widoczny dla zalogowanych], to meet the requirements.)
1.3 using SPSS statistical software, measurement data t test.
2 results preoperative ChE activity was (3 118.4 ± 538.6) U / L, ChE activity after replacement for the (4 996.2 ± 625.3 ) U / L, after statistical processing, the difference was significant (t = 7.546, P <0.01), ChE activity after plasma exchange was significantly higher than preoperative.
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